Suppression of Multiple Sclerosis by Ultraviolet Light

The inverse relationship of multiple sclerosis to sunlight exposure was proposed at least 50 years ago but conclusive evidence is unavailable. Since the proposal made, many researchers have jumped conclusion vitamin D mediates this effect. Vitamin a pro-hormone produced in skin by ultraviolet irradiation and/or sun exposure. In addition, an between plasma levels metabolite, 25(OH)D3, and reduced incidence has been noted. As result clinical trials carried out determine if supplementation can suppress disease. results not supported idea. animal model (experimental autoimmune encephalomyelitis) hypothesis refuted. Ultraviolet irradiation, on other hand, consistently reduces severity experimental encephalomyelitis. Because encephalomyelitis widely accepted human sclerosis, testing efficacy narrow band light suppression appear warranted. If fact does isolation identification compound should be initiated.